Forschungsprojekt 2017: Detection and prevention of delirium triggered by adverse drug events

Aus den 5 eingereichten Projekten wählte die Arbeitsgruppe Forschung das Projekt von Frau Dr. Monika Lutters, Kantonsspital Baden mit dem Titel «Detection and prevention of delirium triggered by adverse drug events» aus.

Kurzbeschreibung des Projekts (nur in Englisch verfügbar)

Delirium is a frequent and serious ADE in hospitals. Its prevention may reduce length of hospital stay, mortality and costs, and avoid unnecessary and potentially harmful pharmacological treatment. The manual algorithm (checklist) and automated algorithm (source code) can be implemented in other hospitals, and  be used by clinical pharmacists.

The project is associated with a large interdisciplinary, multicentric research project financed by the Swiss National Foundation (NRP 74, “Automatic detection of adverse drug events in the geriatric care”, where pharmacists, clinical pharmacologists, geriatricians, epidemiologists, specialists in medical informatics, structured data mining and natural language processing closely work together. The experience gained with this project will facilitate the development of other algorithms to prevent ADEs.


  1. To detect drug induced delirium and identify risk factors in different population groups
  2. To prevent drug induced delirium by automatically calculating anticholinergic burden of drug therapy, displaying alerts in CPOE and automatically directing daily lists of orders with candidate medications to experts for review

Vollständige Projektbeschreibung (in Englisch)

Zwischenbericht, Frühling 2018 (in Englisch)

Zwischenbericht, Frühling 2019 (in Englisch)

Zwischenbericht, Sommer 2020 (in Englisch)

Schlussbericht, Sommer 2021 (in Englisch)